Background: Despite the extensive literature focusing on identifying novel antimicrobials of plant origin, little work has been undertaken to examine the antimicrobial activity of wild edible plants. Objective: The current research aimed to determine the in vitro antimicrobial activity of methanolic extract of some common wild edible plants. Material and Methods: Disc diffusion and broth micro dilution methods were used to evaluate the antimicrobial activity of extracts of Mercurialis annua, Ziziphys lotus, Rubia peregrina, Origanum vulgare, Papaver rhoeas, Foeniculum vulgare, and Dysphania ambrosioides against known human microorganisms’ pathogens. Results: The result indicated that most of the extracts exhibited a range of in vitro growth inhibitory action against all bacterial strains and yeasts tested with inhibition zones ranging from 11 mm to 32 mm, MIC value ranging from 0.048 to 50 mg/ml and MBC and MFC values ranging from 0.048 to 100 mg/ml. Among the seven plant extracts tested, O. vulgare was the most effective showing high antimicrobial activity against all tested microbial strains. All plant extracts exhibited bactericidal activities against all the tested bacteria strains except for those of R. peregrina, P. rhoeas and F. vulgare which showed a bacteriostatic activity against E. coli and Pseudomonas sp. Antifungal activity was shown only by O. vulgare, F. vulgare and D. ambrosioides against both C. albicans and C. neoformans. Conclusions: These findings highlight the potential of wild edible plants to control human pathogenic microbes and demonstrate that these plants could be used as starting points for the development of novel antimicrobial compounds.